Second Harmonic Generation – se ind i senerne

Super spændende (og lidt nørdet): Second Harmonic Generation Confocal Microscopy of Collagen Type I

Som jeg skrev tidligere på ugen, har jeg været på besøg hos Dr. Alexander Scott på UBC i Vancouver i denne uge, hvor en af mine phd studerende – Jessica Pingel – er på et halvt års ophold. Det har været et spændende uge, hvor vi blandt andet har startet en række forsøg, hvor vi i samarbejde med Dr. Thomas Abraham skal undersøge, hvad der sker i senevæv, der er skadet. En af de teknikker vi anvender, er Second Harmonic Generation Confocal Microscopy.Teknikken kan scanne ned igennem en biopsi fra en sene og undersøge, hvordan strukturen ser ud, samt afslører om de mindre bestanddele af senen (fibrillerne) ligger alignet, eller om der er tegn på arvævs dannelse. Data kommer i løbet af foråret, men jeg synes lige, du skulle have mulighed for at læse mere om metoden, samt se hvordan en sådan scanning ser ud

Se video her

samt nyde den helt fantastiske udsigt fra laboratoriet i Vancouver.

Læs om Alexander Scotts forskning her

Læs mere om Second Harmonic Generation Confocal Microscopy of Collagen Type I from Rat Tendon Cryosections

About henninglangberg

Position: Senior Researcher, ISMC/Associate Professor, Copenhagen University Title: PT, DSc, PhD, MSc Phone: +45 3531 2710 Email: henninglangberg@gmail.com Research focus The overall focus of our research is to understand the mechanism behind the adaptation of human tendons to changes in load. In studies on in-vivo human tendons we have shown that several growth factors are released in response to physical activity and that load leads to increased collagen synthesis in human connective tissue. This relationship will be further investigated. A better understanding of the link between growth factor release and collagen adaptation would be valuable in as diverse situations as rehabilitation and training, immobilization and inactivity allowing more optimal rehabilitation of patients with tendon problems. Publications - PubMed Doctoral thesis: "Response of tendon associated connective tissue to mechanical loading in humans" 2007 PhD thesis: "The human Achilles tendon – circulatory and metabolic changes with exercise" 2000
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